Later in 2023, Mellencamp gave a devastating update and revealed that she was once again diagnosed with melanoma.
Mellencamp soon shared doctors felt that an excision area was too 'broad' and doctors did not recommend cutting and instead should undergo immunotherapy.
After trying the immunotherapy cream for almost two weeks, Teddi took to Instagram and penned, ''Melanoma Immunotherapy Update: It's been 12 days since I started the immunotherapy cream on my shoulder, and sadly it has not blistered yet.
'Blisters = it's working,' she wrote, adding that her doctors were 'upping the dosage in the hopes that kicks it into gear.
'Otherwise, we are going to have to take next steps - which is a full skin graft of my shoulder, taking the skin from my lower abdomen. Let's just say I have never prayed so hard for some blisters.
'As always, thank you for your love, support and sharing your own stories. This all gives me the strength to push through and continue to share mine.'
A few months later in December 2023, she emotionally revealed that the immunotherapy was unsuccessful - even after upping the dosage. The star eventually chose to go for the second option to have the wide excision surgery.
After the procedure, she updated her fans three months later to show the vast difference of how her large scar had healed.
In July 2024, Mellencamp took to her Instagram page to share graphic photos following melanoma surgery as she prepared to undergo her 16th procedure to remove the disease.
'Thank you to everyone for all the love and support. To answer your main question: My next surgery is August 19th,' she wrote. 'This is #16, I think, and I keep fighting it so I am feeling more positive than a week ago.'
She also got candid about how the 'the ups and downs of not being able to control what's going on inside my own body' was challenging.
Late last year in December, Teddi positively revealed good news and shared she did not need to undergo another biopsy. While sitting inside her car, the star said, 'I just had a little cry, but it's a good one.
'It's the first time in over two years I've gone in for my three-month check and not had to have a biopsy because I have another cancerous spot.'
She reflected how it had been 'such a good feeling' and revealed both she and her doctor looked at each other in shock upon discovering the news.
'I'll go back in March, stay diligent with my checks, and this should be a reminder to all of you guys, please, please, book your skin checks, book your mammograms, book your OB/GYN appointments, book your eye doctor appointments.'
In the caption, she also got candid about having 'anxiety' when it came to her checks and also sent gratitude towards the support and care she has received.
'And if you need to get your skin checked but have yet to make an appointment… what are you waiting for?' she encouragingly asked.
