The reigning powerhouse of the AFC, the Kansas City Chiefs, now know their path for the 2025–26 NFL regular season — and it’s filled with marquee matchups, national spotlight games, and critical divisional clashes.
The Chiefs open their campaign under the bright lights on Friday, September 5, against the Los Angeles Chargers in a rare neutral-site game streamed exclusively on YouTube at 8:00 PM ET. Just nine days later, they return home for a Week 2 showdown with the Philadelphia Eagles (Sep 14, 4:25 PM, FOX), a game that could serve as an early Super Bowl preview.
Week 3 sees Kansas City travel to face the New York Giants on Sunday Night Football (Sep 21, NBC), followed by another high-profile home clash with the Baltimore Ravens (Sep 28, CBS). The schedule’s early portion is a gauntlet, with the Chiefs visiting the Jacksonville Jaguars on Monday Night Football (Oct 6, ABC/ESPN) and then hosting the Detroit Lions under the Thursday night spotlight (Oct 12, NBC).
October continues with a divisional rivalry game at home against the Las Vegas Raiders (Oct 19, CBS) and a Monday night matchup versus the Washington Commanders (Oct 27, ABC/ESPN). They wrap up the first half of the season on the road against the Buffalo Bills (Nov 2, CBS) before hitting their Week 10 bye.
The post-bye stretch will be just as grueling. The Chiefs face back-to-back AFC opponents on the road — Denver Broncos (Nov 16, CBS) and Indianapolis Colts (Nov 23, CBS) — before traveling to Dallas for a Thanksgiving showdown with the Cowboys (Nov 27, CBS/Paramount+). December kicks off with a Sunday night home tilt against the Houston Texans (Dec 7, NBC) and a divisional clash with the Chargers (Dec 14, CBS).
The regular season closes with two tough road trips: Tennessee Titans (Dec 21, CBS) and Denver Broncos again (Dec 28, Prime Video). A Week 18 flex game at Las Vegas could determine playoff positioning — or the AFC West crown itself.
With six prime-time appearances and a schedule stacked with playoff-caliber opponents, the Chiefs’ road to another postseason run will be anything but easy. But if history is any guide, Patrick Mahomes and company thrive under pressure — and 2025–26 will give them every chance to prove it once again.
